Brain Connectivity Center (BCC)

Piano seminterrato – Prima torre
Responsabile: Prof. Egidio D'Angelo
Tel: 0039-0382 -987606
E-mail: dangelo@unipv.it
Scarica il CV

Collaboratori:

1 fisico, specialista in imaging: Dott. Jonathan Mapelli (ricercatore IRCCS)
1 fisico, specialista in modelli computazionali: Dott. Sergio Solinas (ricercatore IRCCS)

Segreteria:
Dr.ssa Irene Solinas
E-mail:irene.solinas@mondino.it

Il “Centro di Ricerca Integrata per lo Studio dei Circuiti Cerebrali” (BRAIN CONNECTIVITY CENTER, BCC) della Fondazione Mondino nasce nel 2009 dall'esigenza di coniugare le ricerche a livello cellulare-molecolare ed anatomo-funzionale sulla connettività del sistema nervoso centrale con le osservazioni cliniche in svariate patologie neurologiche, con lo scopo ultimo di identificare nuovi approcci diagnostici e terapeutici. Comprende il Laboratorio di Neurofisiologia del Dipartimento di Fisiologia dell'Università di Pavia e Unità di Ricerca dell' IRCCS C.Mondino.

Leggi la News del Congresso The Cerebellum: from neurons to higher control and cognition svoltosi l' 8-9 luglio 2010 in Aula Berlucchi presso l'Istituto Nazionale C. Mondino.

Le attività di ricerca del BCC si articolano su 5 principali aree tematiche:

Connetività e funzione dei circuiti cerebrali
Ritmi cerebrali: correlati della coscienza
Neuroplasticità, apprendimento e memoria
Neuropatologia cellulare e molecolare
Tecniche per le Neuroscienze

Il BCC è organizzato secondo il seguente schema:

Pubblicazioni scientifiche rappresentative dell'ultimo quinquennio:

David Gall, Francesca Prestori, Elisabetta Sola, Anna D'Errico, Celine Roussel, Lia Forti, Paola Rossi, and Egidio D'Angelo (2005) Intracellular calcium regulation by burst discharge determines bidirectional long-term synaptic plasticity at the cerebellum input stage. J Neuroscience, 4813-1822.
D'Angelo, E. (2005) Synptic psticity at the cerebellum input stage: mechanisms and functional implications. Arch. It. Biol 143:143-156
Nieus T, Sola E, Mapelli J, Saftenku E, Rossi P, D'Angelo E (2006) Regulation of repetitive neurotransmission and firing by releaSe probability at the input stage of cerebellum: experimental observations and theoretical predictions on the role of LTP. J Neurophysiol 95:686-699.
Jacopo Magistretti, Loretta Castelli and Egidio D'Angelo (2006) Kinetic and functional analysis of transient, persistent, and resurgent sodium currents in rat cerebellar granule cells in situ. J Physiology, 573:83-106.
Paola Rossi, Lisa Mapelli, Leda Roggeri, David Gall, Alban de Kerchove d'Exaerde, Serge N. Schiffmann, Vanni Taglietti, Egidio D'Angelo (2006) Long-lasting inhibition of constitutive inward rectifier currents in cerebellar granule cells by synaptic activation of GABAB receptors. Eur. J. Neuroscience, 24(2):419-432
Lia Forti, Elisabetta Cesana, Jonathan Mapelli and Egidio D'Angelo (2006) Ionic mechanisms of autorhythmic firing in rat cerebellar Golgi cells. J Physiology, 574.3: 711–729
Anna Fassio, Daniela Merlo, Jonathan Mapelli, Andrea Menegon, Anna Corradi, Simona Zappettini, Giambattista Bonanno, Flavia Valtorta, Egidio D'Angelo & Fabio Benfenati. The synapsin domain E accelerates the exo-endocytotic cycle of synaptic vesicles in cerebellar Purkinje cells. J. of Cell Science, 119: :4257-4268
Offenhauser N, Castelletti D, Mapelli L, Soppo BE, Regondi MC, Rossi P, D'Angelo E, Frassoni C, Amadeo A, Tocchetti A, Pozzi B, Disanza A, Guarnieri D, Betsholtz C, Scita G, Heberlein U, Di Fiore PP. (2006) Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell 127(1):213-226.
Jonathan Mapelli, Egidio D'Angelo. (2007) The Spatial Organization of Long-Term Synaptic Plasticity at the Input Stage of Cerebellum. J. Neuroscience 27(6): 1285-1296.
Goldfarb M, Schoorlemmer J, Williams A, Mukundanunny SD, Huang X, Giza J, Tchetchik D, Kelley K, Vega A, Matthews G, Rossi P, Ornitz D, and D'Angelo E (2007) Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron,55:449-463
Sergio Solinas, Lia Forti, Elisabetta Cesana, Jonathan Mapelli, Erik De Schutter, Egidio D'Angelo. (2007) Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells. Frontiers in Cellular Neuroscience 1-2:1-12.
Sergio Solinas, Lia Forti, Elisabetta Cesana, Jonathan Mapelli, Erik De Schutter, Egidio D'Angelo. (2007) Fast-reset of pacemaking and theta-frequency resonance patterns in cerebellar Golgi cells. Frontiers in Cellular Neuroscience 1-4:1-9 .
Roggeri L, Rivieccio B, Rossi P, D'Angelo E (2008) Tactile stimulation evokes long-term synaptic plasticity in the granular layer of cerebellum. J Neuroscience, 28:6354-6359
Francesca Prestori, Paola Rossi, Bertrand Bearzatto, Jeanne Lainé, Daniela Necchi, Shyam Diwakar, Serge N. Schiffmann, Herbert Axelrad, Egidio D'Angelo (2008) Altered neuron excitability and synaptic plasticity in the cerebellar granular layer of juvenile prion protein knock-out mice with impaired motor control. J Neuroscience, 28:7091-2103.
D'Angelo. The critical role of Golgi cells in regulating spatio-temporal integration and plasticity at the cerebellum input stage. Frontiers in Cellular Neuroscience, 2: 35-46.
L. Sacconi, J. Mapelli, D. Gandolfi, J. Lotti, R. P. O'Connor, E. D'Angelo and F. S. Pavone. Optical recording of electrical activity in intact neuronal networks with random access second-harmonic generation microscopy. Opt. Express 16, 14910-1492
D'Angelo, E., DeZeeuw, C (2008). Timing and plasticity in the cerebellum: focus on the granular layer. TINS, 32(1):30-40.
R Carillo, E Ros, S Tolu, T Nieus, E D'Angelo. (2008) Event-driven simulation of cerebellar granule cells, Biosystems 94:10-7.
Bastianello S, Pezzella FR, D'Angelo E. (2008) Non-invasive imaging of brain structure and function in neural connectivity analysis. Funct Neurol 23:169-170
Shyam Diwakar, Jacopo Magistretti, Mitchell Goldfarb, Giovanni Naldi, Egidio D'Angelo. Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells. J Neurophysiology 101(2):519-32
Mapelli L, Rossi P, Nieus T, D'Angelo E . Tonic activation of GABA-B receptors reduces release probability at inhibitory connections in the cerebellar glomerulus. J Neurophysiology. 101:3089-3099
D'Angelo E, Koekkoek SK, Lombardo P, Solinas S, Ros E, Garrido J, Schonewille M, De Zeeuw CI. (2009) Timing in the cerebellum: oscillations and resonance in the granular layer. Neuroscience. PMID: 19409229
Anna D'Errico, Francesca Prestori and Egidio D'Angelo (2009) Differential induction of bidirectional long-term changes in neurotransmitter release by frequency-coded patterns at the cerebellar input. J Physiology, 2009, pp 1–15.
Sergio Solinas, Thierry Nieus3 and Egidio D'Angelo (2010). A realistic large-scale model of the cerebellum granular layer predicts circuit spatio-temporal ﬁltering properties. Frontiers in CELLULAR NEUROSCIENCE, April 2010, volume 4, article 12.
Egidio D'Angelo. (2010) on "Homeostasis of intrinsic excitability: making the point". J Physiol 588.6 (2010) pp 901–902
Jonathan Mapelli, Daniela Gandolﬁ, and Egidio D'Angelo. (2010) Combinatorial Responses Controlled by Synaptic Inhibition in the Cerebellum Granular Layer. J Neurophysiol 103: 250 – 261.
Arleo A, Nieus T, Bezzi M, D'Errico A, D'Angelo E, Coenen OJ.. How synaptic release probability shapes neuronal transmission: information-theoretic analysis in a cerebellar granule cell. Neural Comput. 2010 Aug;22(8):2031-58.
Boso M, Emanuele E, P F, Politi P, Barale F, D'Angelo E.Autism and genius: is there a link? The involvement of central brain loops and hypotheses for functional testing. Funct Neurol. 2010 Jan/Mar;25(1):15-20
Galliano E, Mazzarello P, D'Angelo E. Discovery and rediscoveries of Golgi cells. J Physiol. 2010 Jun 25.
Mapelli J, Gandolfi D, D'Angelo E. High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum. Front Cell Neurosci. 2010 May 28;4:14

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